Palladium-catalyzed carbonylative cyclization of 2-alkynylanilines and aryl iodides to access N-acyl indoles

Lingyun Yao; Yan Shang; Jian-Shu Wang; Ailin Pan; Jun Ying; Xiao-Feng Wu

doi:10.1039/D1QO00205H

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Palladium-catalyzed carbonylative cyclization of 2-alkynylanilines and aryl iodides to access N-acyl indoles†

Lingyun Yao,^a Yan Shang,^a Jian-Shu Wang,^a Ailin Pan,^a Jun Ying

*^a and Xiao-Feng Wu

*^bc

Author affiliations

* Corresponding authors

^a Department of Chemistry, Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou 310018, China
E-mail: yingjun@zstu.edu.cn

^b Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, Liaoning, China
E-mail: xwu2020@dicp.ac.cn

^c Leibniz-Institut für Katalyse e. V. an der Universität Rostock, Albert-Einstein-Straβe 29a, 18059 Rostock, Germany
E-mail: xiao-feng.wu@catalysis.de

Abstract

A palladium-catalyzed carbonylative synthesis of N-acyl indoles from 2-alkynylanilines and aryl iodides has been developed. Using benzene-1,3,5-triyl triformate (TFBen) as the CO source, the reaction produced a variety of N-acyl indoles in a facile manner with high yields.

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Article information

DOI: https://doi.org/10.1039/D1QO00205H
Article type: Research Article
Submitted: 04 Feb 2021
Accepted: 17 Feb 2021
First published: 19 Feb 2021

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Org. Chem. Front., 2021,8, 1926-1929

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Palladium-catalyzed carbonylative cyclization of 2-alkynylanilines and aryl iodides to access N-acyl indoles

L. Yao, Y. Shang, J. Wang, A. Pan, J. Ying and X. Wu, Org. Chem. Front., 2021, 8, 1926 DOI: 10.1039/D1QO00205H

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Palladium-catalyzed carbonylative cyclization of 2-alkynylanilines and aryl iodides to access N-acyl indoles†

Abstract

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Palladium-catalyzed carbonylative cyclization of 2-alkynylanilines and aryl iodides to access N-acyl indoles

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