Issue 20, 2021

Copper-catalyzed redox neutral ketoalkylation of Csp2–H bonds via C–C bond cleavage

Abstract

An efficient copper-catalyzed ketoalkylation of Csp2–H bonds with cycloalkyl silyl peroxides under mild and redox neutral conditions is presented. Relying on the C–C bond cleavage, a series of distal ketoalkyl moieties were successfully incorporated into the specific position of quinoxalin-2(1H)-ones, heteroaromatic N-oxides and quinones with moderate to good yields.

Graphical abstract: Copper-catalyzed redox neutral ketoalkylation of Csp2–H bonds via C–C bond cleavage

Supplementary files

Article information

Article type
Research Article
Submitted
12 Jun 2021
Accepted
23 Aug 2021
First published
24 Aug 2021

Org. Chem. Front., 2021,8, 5866-5871

Copper-catalyzed redox neutral ketoalkylation of Csp2–H bonds via C–C bond cleavage

H. Chen, L. Guo, Q. Sun, L. Chen, J. Tao and P. Gao, Org. Chem. Front., 2021, 8, 5866 DOI: 10.1039/D1QO00882J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements