I2-Catalyzed oxidative dehydrogenative tandem cyclization of 2-methylquinolines, arylamines and 1,4-dioxane

Abstract

A novel I₂-catalyst oxidative dehydrogenative tandem cyclization of three components, 2-methylquinolines, arylamines and 1,4-dioxane, for the construction of 2-([2,2′-biquinolin]-3-yloxy)ethan-1-ol derivatives has been developed under metal-free conditions. This transformation with the cleavage of 7 C–H bonds, 2 N–H bonds and 1 C–O bond leads to the construction of 2 C–C bonds, 1 C–N bond and 1 O–H bond. The 1,4-dioxane ring was opened and a 2-(vinyloxy)ethan-1-ol group was obtained in the whole process.