Three-component photoredox 1,2-alkylamination of styrenes with alkanes and nitrogen nucleophiles via C(sp3)–H bond cleavage

Abstract

A three-component photoredox 1,2-alkylamination of styrenes involving functionalization of C(sp³)–H bonds in alkyl halides instead of functionalization of C-halogen bonds is disclosed. A variety of commercialized C(sp³)–H alkanes, including dichloromethane, acetonitrile, and acetone, used as alkyl radical precursors and solvents, were compatible with this methodology. The mechanistic study shows that alkyl radicals are generated by hydrogen atom transfer (HAT) between aryl radicals and alkyl halides.