Issue 9, 2021

Mechanically induced solvent-free esterification method at room temperature

Abstract

Herein, we describe two novel strategies for the synthesis of esters, as achieved under high-speed ball-milling (HSBM) conditions at room temperature. In the presence of I2 and KH2PO2, the reactions afford the desired esterification derivatives in 45% to 91% yields within 20 min of grinding. Meanwhile, using KI and P(OEt)3, esterification products can be obtained in 24% to 85% yields after 60 min of grinding. In addition, the I2/KH2PO2 protocol was successfully extended to the late-stage diversification of natural products showing the robustness of this useful approach. Further application of this method in the synthesis of inositol nicotinate was also discussed.

Graphical abstract: Mechanically induced solvent-free esterification method at room temperature

Supplementary files

Article information

Article type
Paper
Submitted
06 Nov 2020
Accepted
12 Jan 2021
First published
28 Jan 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 5080-5085

Mechanically induced solvent-free esterification method at room temperature

L. Zheng, C. Sun, W. Xu, A. V. Dushkin, N. Polyakov, W. Su and J. Yu, RSC Adv., 2021, 11, 5080 DOI: 10.1039/D0RA09437D

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