Issue 9, 2021

Enhancing the biological activity of polyoxometalate–peptide nano-fibrils by spacer design

Abstract

Polyoxometalates (POMs) and peptides can be conjugated to yield novel bio-hybrids with potential application as nanodrugs. However, the observed POM-induced folding of the peptide prevents its availability towards biological targets. An Anderson–Evans POM was functionalized with a bombesin analog peptide and engineered by adding a tailored hydrophilic and anionic spacer between the two moieties, to make the targeting sequence more accessible and enable an unprecedented cancer cell recognition capability.

Graphical abstract: Enhancing the biological activity of polyoxometalate–peptide nano-fibrils by spacer design

Supplementary files

Article information

Article type
Paper
Submitted
03 Dec 2020
Accepted
16 Jan 2021
First published
26 Jan 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 4952-4957

Enhancing the biological activity of polyoxometalate–peptide nano-fibrils by spacer design

V. Tagliavini, C. Honisch, S. Serratì, A. Azzariti, M. Bonchio, P. Ruzza and M. Carraro, RSC Adv., 2021, 11, 4952 DOI: 10.1039/D0RA10218K

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