Issue 12, 2021, Issue in Progress

Synthesis of monodisperse magnetic restricted microspheres for recognition of thiamphenicol in milk

Abstract

Taking thiamphenicol as the research object, a new type of magnetic restricted access molecularly imprinted polymer (RAM-MMIP) with specific recognition was prepared by a one-step swelling method. The polymer microspheres were characterized and analyzed by scanning electron microscopy, X-ray diffraction, elemental analysis, contact angle measurement and vibrating sample magnetometry. When the ratio of template molecule, functional monomer and cross linking agent was 1 : 4 : 8, the adsorption capacity reached the maximum. Under these conditions, RAM-MIP magnetic solid phase extraction (M-SPE) was combined with HPLC to analyze thiamphenicol in milk samples. Satisfactory linear correlation (R2 > 0.9977), good detection limit (LOD: 10.4 μg L−1), high recovery rate (96.5–101.1%), and relative standard deviation (RSD: 2.8–3.8%) were obtained. Therefore, our synthesized material can be used for the analysis of TAP in complex milk samples, and has broad application value.

Graphical abstract: Synthesis of monodisperse magnetic restricted microspheres for recognition of thiamphenicol in milk

Supplementary files

Article information

Article type
Paper
Submitted
05 Dec 2020
Accepted
13 Jan 2021
First published
10 Feb 2021
This article is Open Access
Creative Commons BY license

RSC Adv., 2021,11, 6869-6876

Synthesis of monodisperse magnetic restricted microspheres for recognition of thiamphenicol in milk

S. Zhang, H. Liu, T. Cai, Y. Zhou, J. Li, X. Wang, S. Zhao, C. Bo and B. Gong, RSC Adv., 2021, 11, 6869 DOI: 10.1039/D0RA10268G

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