Issue 7, 2021, Issue in Progress
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RSC Advances

Knecorticosanones C–H from the fruits of Knema globularia (Lam.) warb†

Chindawadee Chuenban,a   Aonnicha Sombatsri,a   Thurdpong Sribuhom,a   Chanakan Pornchoo,b   Auemduan Prawan, ORCID logo b   Sarawut Tontapha, ORCID logo c   Vittaya Amornkitbamrung ORCID logo c  and  Chavi Yenjai ORCID logo *a  

* Corresponding authors

a Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand
E-mail: chayen@kku.ac.th
Tel: +66-4320-2222-41 ext. 12243

b Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand

c Integrated Nanotechnology Research Centre, Department of Physics, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand

Abstract

Six undescribed polyketides, 1–6, were discovered from the fruits of Knema globularia (Lam.) warb. Two known polyketides and three known lignans were also isolated. Cytotoxicities against HepG2 and KKU-M156 cells of all polyketides were evaluated. Compound 1 displayed the most cytotoxic activity against HepG2 and KKU-M156 cell lines with IC50 values of 1.57 ± 0.37 and 1.78 ± 0.14 μg mL−1, respectively. The structure of all isolates was identified using spectroscopic methods including NMR, IR, MS and ECD.

Graphical abstract: Knecorticosanones C–H from the fruits of Knema globularia (Lam.) warb

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Article information

DOI
https://doi.org/10.1039/D0RA10498A
Article type
Paper
Submitted
14 Dec 2020
Accepted
29 Dec 2020
First published
20 Jan 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 4097-4103

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Knecorticosanones C–H from the fruits of Knema globularia (Lam.) warb

C. Chuenban, A. Sombatsri, T. Sribuhom, C. Pornchoo, A. Prawan, S. Tontapha, V. Amornkitbamrung and C. Yenjai, RSC Adv., 2021, 11, 4097 DOI: 10.1039/D0RA10498A

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