Issue 14, 2021, Issue in Progress

A reduced graphene oxide-β-cyclodextrin nanocomposite-based electrode for electrochemical detection of curcumin

Abstract

Curcumin is a polyphenolic compound with anti-oxidative and anti-cancer properties that is obtained from turmeric plants. Several studies have demonstrated that cancer cells are not killed unless they are exposed to 5–50 mM of curcumin. Consequently, it is vital to control the concentration of curcumin in cancer therapy. In this study, a sensitive electrochemical sensor was fabricated based on a beta-cyclodextrin–reduced graphene oxide (β-CD–rGO) nanocomposite for measuring curcumin concentration. The effects of experimental factors were investigated and the optimum parametric conditions were determined using the Taguchi optimization method. The β-CD–rGO modified electrode exhibited good electrochemical properties for curcumin detection. The results of differential pulse voltammetry experiments unveiled that the sensor shows a linear response to curcumin concentration over the range of 0.05–10 mM with a detection limit of 33 nM and sensitivity of 4.813 μA μM−1. The fabricated sensor exhibited selectivity in the presence of other electroactive species, e.g., propranolol, clomipramine and clonazepam.

Graphical abstract: A reduced graphene oxide-β-cyclodextrin nanocomposite-based electrode for electrochemical detection of curcumin

Supplementary files

Article information

Article type
Paper
Submitted
21 Dec 2020
Accepted
26 Jan 2021
First published
18 Feb 2021
This article is Open Access
Creative Commons BY license

RSC Adv., 2021,11, 7862-7872

A reduced graphene oxide-β-cyclodextrin nanocomposite-based electrode for electrochemical detection of curcumin

B. Mirzaei, A. Zarrabi, A. Noorbakhsh, A. Amini and P. Makvandi, RSC Adv., 2021, 11, 7862 DOI: 10.1039/D0RA10701H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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