In recent years, preparation of fully protected trinucleotide phosphoramidites as synthons for the codon-based synthesis of gene libraries as well as for the assembly of oligonucleotides from blockmers has gained much attention. We here describe the preparation of such trinucleotide synthons on a soluble support using a disulphide linker.
R. Suchsland, B. Appel, P. Virta and S. Müller, RSC Adv., 2021, 11, 3892 DOI: 10.1039/D0RA10941J
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