Issue 30, 2021, Issue in Progress
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RSC Advances

Enzymatic dephosphorylation-triggered self-assembly of DNA amphiphiles†

Jianmei Zou, ORCID logo ‡*ab   Qian Gao,‡a   Jinfang Nie,a   Yun Zhanga  and  Cheng Jin ORCID logo *c  

* Corresponding authors

a Guangxi Key Laboratory of Electrochemical and Magnetochemical Function Materials, College of Chemistry and Bioengineering, Guilin University of Technology, 12 Jiangan Road, Guilin 541004, China
E-mail: 2019136@glut.edu.cn

b Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China

c Institute of Molecular Medicine (IMM), Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China
E-mail: jinch@hnu.edu.cn

Abstract

In this work, phosphorylated lipid-conjugated oligonucleotide (DNA-lipid-P) has been synthesized to develop an enzyme-responsive self-assembly of DNA amphiphiles based on dephosphorylation-induced increase of hydrophobicity. Since elevated ALP level is a critical index in some diseases, ALP-triggered self-assembly of DNA amphiphiles shows promise in disease diagnosis and cancer treatment.

Graphical abstract: Enzymatic dephosphorylation-triggered self-assembly of DNA amphiphiles

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Article information

DOI
https://doi.org/10.1039/D1RA01668G
Article type
Paper
Submitted
03 Mar 2021
Accepted
07 May 2021
First published
21 May 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 18322-18325

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Enzymatic dephosphorylation-triggered self-assembly of DNA amphiphiles

J. Zou, Q. Gao, J. Nie, Y. Zhang and C. Jin, RSC Adv., 2021, 11, 18322 DOI: 10.1039/D1RA01668G

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