Novel Schiff base cobalt(ii) phthalocyanine with appliance of MWCNTs on GCE: enhanced electrocatalytic activity behaviour of α-amino acids

Abstract

A novel tetra-4-{(E)-[(8-aminonaphthalen-1-yl)imino]methyl}-2-methoxyphenol Co(II) phthalocyanine (CoTANImMMPPc) was synthesized using a precursor protocol and characterized via electroanalytical and spectroscopic techniques. The FT-IR spectra of the synthesized compounds showed significant peaks corresponding to the functional groups of the precursors and phthalocyanine (Pc) compound. The mass and NMR spectra confirmed the formation of the target precursor compounds. A film of CoTANImMMPPc was deposited on the surface of an electrode and applied for the detection and monitoring of L-alanine and L-arginine. The cyclic voltammetric studies of L-alanine and L-arginine using the (CoTANImMMPPc/MWCNTs/GC) electrode showed a linear response in the range of 50–500 nM and the limit of detection was found to be 1.5 and 1.2 nM, respectively. Differential pulse voltammetry and chronoamperometry showed that the catalytic response for L-alanine and L-arginine is in the range of 50–500 nM with an LoD of 1.8 and 2.3 nM, respectively. The oxidation-active CoTANImMMPPc film significantly enhanced the current response in the chronoamperometric method and displayed a selective and sensitive response towards L-alanine and L-arginine in the presence of various other bio-molecules. The developed electrode showed good working stability and was applied for the analysis of real samples, which yielded satisfactory results. Therefore, CoTANImMMPPc-MWCNTs/GCE shows good analytical performance, is economical and produced via a simple synthetic method and can be applied as a sensor for the detection of L-alanine and L-arginine.