Issue 32, 2021, Issue in Progress
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RSC Advances

A facile method for Rh-catalyzed decarbonylative ortho-C–H alkylation of (hetero)arenes with alkyl carboxylic acids†

Yiqiang Tian,ab   Xiaojie Liu,ab   Bangyue He,b   Yuxi Ren*b  and  Weiping Su ORCID logo *b  

* Corresponding authors

a College of Chemistry, Fuzhou University, Fuzhou 350116, China

b State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, China
E-mail: wpsu@fjirsm.ac.cn, yxren@fjirsm.ac.cn

Abstract

A facile and effective method for Rh-catalyzed direct ortho-alkylation of C–H bonds in (hetero)arenes with commercially available carboxylic acids has been developed. This strategy was initiated by in situ conversion of carboxylic acids to anhydrides which, without isolation, underwent Rh-catalyzed direct decarbonylative cross-coupling of aryl carboxamides containing 8-aminoquinoline. The reaction proceeds with high regioselectivity and exhibits a broad substrate scope as well as functional group tolerance.

Graphical abstract: A facile method for Rh-catalyzed decarbonylative ortho-C–H alkylation of (hetero)arenes with alkyl carboxylic acids

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Article information

DOI
https://doi.org/10.1039/D1RA03992J
Article type
Paper
Submitted
22 May 2021
Accepted
26 May 2021
First published
02 Jun 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 19827-19831

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A facile method for Rh-catalyzed decarbonylative ortho-C–H alkylation of (hetero)arenes with alkyl carboxylic acids

Y. Tian, X. Liu, B. He, Y. Ren and W. Su, RSC Adv., 2021, 11, 19827 DOI: 10.1039/D1RA03992J

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