Design, preparation, and characterization of CS/PVA/SA hydrogels modified with mesoporous Ag2O/SiO2 and curcumin nanoparticles for green, biocompatible, and antibacterial biopolymer film

Abstract

One of the most significant factors affecting the rapid and effective healing of wounds is the application of appropriate wound dressings. In the present study, novel antibacterial wound dressings are fabricated that consist of Chitosan (CS)/Polyvinyl alcohol (PVA)/Sodium Alginate (SA), which are all biocompatible, functionalized with mesoporous Ag₂O/SiO₂ and curcumin nanoparticles as reinforcements. In this research nanocomposites are fabricated (0 wt%, 5 wt%, 10 wt%, 15 wt%, and 20 wt% of Ag₂O/SiO₂). After the composition of nanocomposites using the cross-linked technique, Fourier Transform Infrared (FT-IR) spectroscopy is performed to confirm the functional groups that are added to the polymer at each step. X-ray diffraction (XRD) is done to show the crystallinity of Ag₂O/SiO₂. Field emission scanning electron microscopy (FE-SEM) studies are performed to demonstrate the morphology of the structure, Energy-dispersive X-ray spectroscopy (EDS) is done to examine the elements in the wound dressing and atomic force microscopy (AFM) study is performed to show surface roughness and pores. Then the nanocomposites with different weight percentages are cultured in three bacteria called Acinetobacter baumannii, Staphylococcus epidermidis, and Proteus mirabilis, all three of which cause skin infections. Finally, by performing the tensile test, the results related to the tensile strength of the wound dressings are examined. The results show that with the increase of Ag₂O/SiO₂, the mechanical properties, as well as the healing properties of the wound dressing, have increased significantly. Fabricating these nanocomposites helps a lot in treating skin infections.