Decagram scale synthesis of favipiravir was performed in 9 steps using diethyl malonate as cheap starting material. Hydrogenation and bromination steps were achieved by employing a continuous flow reactor. The synthetic process provided a total of 16% yield and it is suitable for larger-scale synthesis and production.
T. Tiyasakulchai, N. Charoensetakul, T. Khamkhenshorngphanuch, C. Thongpanchang, O. Srikun, Y. Yuthavong and N. Srimongkolpithak, RSC Adv., 2021, 11, 38691 DOI: 10.1039/D1RA06963B
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