Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy

Wei-Tao Dou; Fugui Xu; Chen-Xi Xu; Jie Gao; Hong-Bo Ru; Xiangfeng Luan; Jiacheng Zhang; Ling Zhu; Adam C. Sedgwick; Guo-Rong Chen; Yi Zang; Tony D. James; He Tian; Jia Li; Yiyong Mai; Xiao-Peng He

doi:10.1039/D1SC02154K

Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy†

Wei-Tao Dou,

‡^a Fugui Xu,‡^b Chen-Xi Xu,^ac Jie Gao,^ac Hong-Bo Ru,^c Xiangfeng Luan,

^b Jiacheng Zhang,

^b Ling Zhu,^ac Adam C. Sedgwick,

^d Guo-Rong Chen,^a Yi Zang,^c Tony D. James,

^ef He Tian,

^a Jia Li,*^c Yiyong Mai

*^b and Xiao-Peng He

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, Frontiers Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, 130 Meilong RD, Shanghai 200237, P. R. China
E-mail: xphe@ecust.edu.cn

^b School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing, Shanghai Jiao Tong University, 800 Dongchuan RD, Shanghai 200240, P. R. China
E-mail: mai@sjtu.edu.cn

^c National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shoujing Rd., Shanghai 201203, P. R. China
E-mail: jli@simm.ac.cn

^d Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712-1224, USA

^e Department of Chemistry, University of Bath, Bath, UK

^f School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China

Abstract

Triple negative breast cancer (TNBC) is one of the most malignant subtypes of breast cancer. Here, we report the construction of graphene nanoribbon (GNR)-based supramolecular ensembles with dual-receptor (mannose and α_vβ₃ integrin receptors) targeting function, denoted as GNR-Man/PRGD, for targeted photothermal treatment (PTT) of TNBC. The GNR-Man/PRGD ensembles were constructed through the solution-based self-assembly of mannose-grafted GNRs (GNR-Man) with a pyrene-tagged α_vβ₃ integrin ligand (PRGD). Enhanced PTT efficacies were achieved both in vitro and in vivo compared to that of the non-targeting equivalents. Tumor-bearing live mice were administered (tail vein) with GNR-Man/PRGD and then each mice group was subjected to PTT. Remarkably, GNR-Man/PRGD induced complete ablation of the solid tumors, and no tumor regrowth was observed over a period of 15 days. This study demonstrates a new and promising platform for the development of photothermal nanomaterials for targeted tumor therapy.

Chemical Science

Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy†

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Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy

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