Issue 17, 2022

Dual-emissive EY/UiO-66-NH2 as a ratiometric probe for turn-on sensing and cell imaging of hypochlorite

Abstract

Hypochlorite plays a vital role in biological systems and our daily life. The rapid and convenient detection of hypochlorite is imperative and significant for disease treatment and human health. In this work, EY/UiO-66-NH2 (EY = eosin Y) was prepared through a hydrothermal process and could be applied to the detection and bioimaging of hypochlorite as a self-calibrating sensing nanoprobe. EY/UiO-66-NH2 features two emissions at 432 nm and 533 nm, and the emission intensity of 533 nm is enhanced with increasing ClO concentration. EY/UiO-66-NH2 could be utilized as a ratiometric fluorescence sensor of ClO. The linear range of EY/UiO-66-NH2 towards ClO is 0.1–200 μM and its detection limit is 46.4 nM. In comparison with previously reported probes for ClO, EY/UiO-66-NH2 has the advantages of a wide linear range, low detection limit, turn-on fluorescence and ratiometric response. This work provides a new method for ClO detection in living cells.

Graphical abstract: Dual-emissive EY/UiO-66-NH2 as a ratiometric probe for turn-on sensing and cell imaging of hypochlorite

Supplementary files

Article information

Article type
Paper
Submitted
08 Jun 2022
Accepted
13 Jul 2022
First published
15 Jul 2022

Analyst, 2022,147, 3867-3875

Dual-emissive EY/UiO-66-NH2 as a ratiometric probe for turn-on sensing and cell imaging of hypochlorite

F. Yu, Y. Wang, T. Liu, X. Liu, H. Jiang and X. Wang, Analyst, 2022, 147, 3867 DOI: 10.1039/D2AN00944G

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