Issue 16, 2022
From the journal:

Biomaterials Science

Enhanced antibacterial activity of surface re-engineered lysozyme against Gram-negative bacteria without accumulated resistance†

Zhenhui Li, ORCID logo a   Song Lin,a   Mei Zhu,a   Lei Wang, ORCID logo a   Xiaoman Liu*a  and  Xin Huang ORCID logo *a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, China
E-mail: liuxiaoman@hit.edu.cn, xinhuang@hit.edu.cn
Fax: +86-451-86413709

Abstract

In this study, we show a way to improve the antibacterial activity of lysozyme by incorporating guanidino functional groups onto its surface (Lyz-Gua), which could treat pathogenic bacteria without accumulated resistance and shows advantages over commercial antibiotics.

Graphical abstract: Enhanced antibacterial activity of surface re-engineered lysozyme against Gram-negative bacteria without accumulated resistance

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Article information

DOI
https://doi.org/10.1039/D2BM00868H
Article type
Communication
Submitted
01 Jun 2022
Accepted
03 Jul 2022
First published
08 Jul 2022

Biomater. Sci., 2022,10, 4474-4478

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Enhanced antibacterial activity of surface re-engineered lysozyme against Gram-negative bacteria without accumulated resistance

Z. Li, S. Lin, M. Zhu, L. Wang, X. Liu and X. Huang, Biomater. Sci., 2022, 10, 4474 DOI: 10.1039/D2BM00868H

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