Issue 12, 2022
From the journal:

Chemical Communications

An activatable and tumor-targeting NIR fluorescent probe for imaging of histone deacetylase 6 in cancer cells and in vivo†

Min Li,a   Jin Liu,a   Xuefei Chen,a   Yijing Dang,a   Yong Shao, ORCID logo b   Zhiai Xu ORCID logo *a  and  Wen Zhang ORCID logo *a  

* Corresponding authors

a School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China
E-mail: zaxu@chem.ecnu.edu.cn, wzhang@chem.ecnu.edu.cn

b College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua, Zhejiang 321004, China

Abstract

An activatable and tumor-targeting near-infrared (NIR) fluorescent probe CyAc-RGD was synthesized for the imaging of histone deacetylase 6 (HDAC6). The probe exhibited higher sensitivity and specificity for HDAC6 detection in cancer cells. Moreover, CyAc-RGD demonstrated good tumor-targeting ability and realized HDAC6 imaging in vivo.

Graphical abstract: An activatable and tumor-targeting NIR fluorescent probe for imaging of histone deacetylase 6 in cancer cells and in vivo

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D1CC04640C
Article type
Communication
Submitted
20 Aug 2021
Accepted
04 Jan 2022
First published
19 Jan 2022

Chem. Commun., 2022,58, 1938-1941

Permissions

Request permissions

An activatable and tumor-targeting NIR fluorescent probe for imaging of histone deacetylase 6 in cancer cells and in vivo

M. Li, J. Liu, X. Chen, Y. Dang, Y. Shao, Z. Xu and W. Zhang, Chem. Commun., 2022, 58, 1938 DOI: 10.1039/D1CC04640C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements