Issue 3, 2022
From the journal:

Chemical Communications

New approaches to ondansetron and alosetron inspire a versatile, flow photochemical method for indole synthesis†‡

Wei Sun,*a   William A. T. Raimbach,a   Luke D. Elliott,b   Kevin I. Booker-Milburn ORCID logo b  and  David C. Harrowven ORCID logo *a  

* Corresponding authors

a Chemistry, University of Southampton, Highfield, Southampton, UK
E-mail: dch2@soton.ac.uk

b School of Chemistry, University of Bristol, Cantock's Close, Bristol, UK

Abstract

An oxidative photocyclisation of N-arylenaminones to indoles is described, that mirrors the Fischer indole synthesis but uses anilines in place of arylhydrazines. Its value is exemplified with new approaches to the WHO-listed APIs ondansetron and alosetron.

Graphical abstract: New approaches to ondansetron and alosetron inspire a versatile, flow photochemical method for indole synthesis

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Article information

DOI
https://doi.org/10.1039/D1CC05700F
Article type
Communication
Submitted
08 Oct 2021
Accepted
26 Nov 2021
First published
26 Nov 2021
This article is Open Access
Creative Commons BY license

Chem. Commun., 2022,58, 383-386

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New approaches to ondansetron and alosetron inspire a versatile, flow photochemical method for indole synthesis

W. Sun, W. A. T. Raimbach, L. D. Elliott, K. I. Booker-Milburn and D. C. Harrowven, Chem. Commun., 2022, 58, 383 DOI: 10.1039/D1CC05700F

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