Issue 6, 2022

Room temperature HFIP/Ag-promoted palladium-catalyzed C–H functionalization of benzothiazole with iodoarenes

Abstract

A versatile synthetic protocol involving the room temperature direct arylation of benzothiazole with a wide variety of iodoarenes under Ag-promoted Pd-catalyzed conditions in HFIP as the reaction solvent has been presented. A sequential HFIP-promoted selective iodination of arenes followed by Pd-catalyzed direct arylation of benzothiazole has also been disclosed. The utility of the developed protocol has been demonstrated by the synthesis of anti-tumor agents, PMX-610 and CJM-126 (precursor).

Graphical abstract: Room temperature HFIP/Ag-promoted palladium-catalyzed C–H functionalization of benzothiazole with iodoarenes

Supplementary files

Article information

Article type
Communication
Submitted
27 Oct 2021
Accepted
14 Dec 2021
First published
14 Dec 2021

Chem. Commun., 2022,58, 847-850

Room temperature HFIP/Ag-promoted palladium-catalyzed C–H functionalization of benzothiazole with iodoarenes

S. Kori, Y. Bhujbal, K. Vadagaonkar, A. R. Kapdi, S. P. Kommyreddy and S. J. Gharpure, Chem. Commun., 2022, 58, 847 DOI: 10.1039/D1CC06063E

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