Considering that the pH in the tumor microenvironment is dysregulated, we designed a β-hairpin peptide (SSRFEWEFESSDPRGDPSSRFEWEFESS). The configuration of the peptide switched from a flexible linear to a rigid loop structure under weakly acidic conditions. The peptide internalized by tumor cells increased significantly under weakly acidic conditions.
S. Nishimura, K. Nishida and M. Tanaka, Chem. Commun., 2022, 58, 505 DOI: 10.1039/D1CC06218B
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