Engineering a multi-target therapy nanoplatform against tumor growth and metastasis via a novel NSAID-Pt(IV) prodrug

Di Zhang; Jing Nie; Dongbo Wang; Huina Wu; Lei Sun; Xuejian Wang; Jiyong Wu

doi:10.1039/D1CC06385E

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Engineering a multi-target therapy nanoplatform against tumor growth and metastasis via a novel NSAID-Pt(iv) prodrug†

Di Zhang,^a Jing Nie,^a Dongbo Wang,^a Huina Wu,^a Lei Sun,^a Xuejian Wang^b and Jiyong Wu

*^a

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* Corresponding authors

^a Department of Pharmacy, Shandong Second Provincial General Hospital, 4 West Duanxing Road, Jinan, Shandong Province 250022, China
E-mail: wujiyongsdcn@gmail.com

^b School of Pharmacy, Weifang Medical University, Weifang, Shandong Province 261053, China

Abstract

Tumor growth and metastasis are caused by many factors. The complexity means that a multi-target combination therapy strategy should be selected against tumor growth and metastasis. Here, cisplatin (CDDP) and bendazac (Ben) were designed as a novel NSAID-Pt(IV) nanoplatform, which is an effective weapon for combating tumor growth and metastasis.

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Article information

DOI: https://doi.org/10.1039/D1CC06385E
Article type: Communication
Submitted: 12 Nov 2021
Accepted: 18 Feb 2022
First published: 21 Feb 2022

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Chem. Commun., 2022,58, 3803-3806

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Engineering a multi-target therapy nanoplatform against tumor growth and metastasis via a novel NSAID-Pt(IV) prodrug

D. Zhang, J. Nie, D. Wang, H. Wu, L. Sun, X. Wang and J. Wu, Chem. Commun., 2022, 58, 3803 DOI: 10.1039/D1CC06385E

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Chemical Communications

Engineering a multi-target therapy nanoplatform against tumor growth and metastasis via a novel NSAID-Pt(iv) prodrug†

Abstract

Supplementary files

Article information

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Engineering a multi-target therapy nanoplatform against tumor growth and metastasis via a novel NSAID-Pt(IV) prodrug

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