Cyclic poly(β-amino ester)s with enhanced gene transfection activity synthesized through intra-molecular cyclization

Chenfei Wang; Xiaobei Huang; Litao Sun; Qiuxia Li; Zhili Li; Haiyang Yong; Delu Che; Cong Yan; Songmei Geng; Wenxin Wang; Dezhong Zhou

doi:10.1039/D1CC06480K

Cyclic poly(β-amino ester)s with enhanced gene transfection activity synthesized through intra-molecular cyclization†

Chenfei Wang,‡^a Xiaobei Huang,‡^b Litao Sun,^a Qiuxia Li,^a Zhili Li,^a Haiyang Yong,^a Delu Che,^c Cong Yan,^c Songmei Geng,*^c Wenxin Wang

^d and Dezhong Zhou

*^a

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* Corresponding authors

^a School of Chemical Engineering and Technology, Xi'an Jiaotong University, Xi'an 710049, China
E-mail: dezhong.zhou@xjtu.edu.cn

^b Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China

^c Department of Dermatology, The Second Hospital Affiliated to Xi'an Jiaotong University, Xi'an 710061, China
E-mail: gsm312@yahoo.com

^d Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin 4, Ireland

Abstract

Topological structure plays a critical role in gene delivery of cationic polymers. Cyclic poly(β-amino ester)s (CPAEs) are successfully synthesized via sequential Michael addition and free radical initiating ring-closure reaction. The CPAEs exhibit superior gene transfection efficiency and safety profile compared to their linear counterparts.

Chemical Communications

Cyclic poly(β-amino ester)s with enhanced gene transfection activity synthesized through intra-molecular cyclization†

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Cyclic poly(β-amino ester)s with enhanced gene transfection activity synthesized through intra-molecular cyclization

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