Issue 6, 2022
From the journal:

Chemical Communications

A simple, rapid and low-cost qPCR assay for evaluating the severity of exosomal PD-L1-mediated T cell exhaustion in blood samples†

Renhui Zhan,ab   Shanshan Wang,c   Wenfei Guo,a   Xiaonan Gao, ORCID logo a   Xiaojun Liu,a   Kehua Xu ORCID logo *a  and  Bo Tang ORCID logo a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, P. R. China
E-mail: xukehua@sdnu.edu.cn

b Medicine & Pharmacy Research Center, Binzhou Medical University, Shandong, P. R. China

c Yantai Vocational College of Culture and Tourism, Yantai, Shandong, P. R. China

Abstract

A novel dual-aptamer activated proximity-induced qPCR assay was developed for the quantitative analysis of exosomal PD-L1 on T cell-exosome complexes in blood samples.

Graphical abstract: A simple, rapid and low-cost qPCR assay for evaluating the severity of exosomal PD-L1-mediated T cell exhaustion in blood samples

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Article information

DOI
https://doi.org/10.1039/D1CC06496G
Article type
Communication
Submitted
18 Nov 2021
Accepted
13 Dec 2021
First published
15 Dec 2021

Chem. Commun., 2022,58, 831-834

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A simple, rapid and low-cost qPCR assay for evaluating the severity of exosomal PD-L1-mediated T cell exhaustion in blood samples

R. Zhan, S. Wang, W. Guo, X. Gao, X. Liu, K. Xu and B. Tang, Chem. Commun., 2022, 58, 831 DOI: 10.1039/D1CC06496G

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