Issue 5, 2022
From the journal:

Chemical Communications

Organoarsenic probes to study proteins by NMR spectroscopy†

Mithun C. Mahawaththa,‡a   Henry W. Orton,‡b   Ibidolapo Adekoya,a   Thomas Huber,a   Gottfried Otting ORCID logo *b  and  Christoph Nitsche ORCID logo *a  

* Corresponding authors

a Research School of Chemistry, Australian National University, Canberra, ACT 2601, Australia
E-mail: christoph.nitsche@anu.edu.au

b ARC Centre of Excellence for Innovations in Peptide and Protein Science, Research School of Chemistry, Australian National University, Canberra, ACT 2601, Australia
E-mail: gottfried.otting@anu.edu.au

Abstract

Arsenical probes enable structural studies of proteins. We report the first organoarsenic probes for nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) spectroscopy to study proteins in solutions. These probes can be attached to irregular loop regions. A lanthanide-binding tag induces sizable pseudocontact shifts in protein NMR spectra of a magnitude never observed for small paramagnetic probes before.

Graphical abstract: Organoarsenic probes to study proteins by NMR spectroscopy

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Article information

DOI
https://doi.org/10.1039/D1CC06497E
Article type
Communication
Submitted
18 Nov 2021
Accepted
15 Dec 2021
First published
15 Dec 2021

Chem. Commun., 2022,58, 701-704

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Organoarsenic probes to study proteins by NMR spectroscopy

M. C. Mahawaththa, H. W. Orton, I. Adekoya, T. Huber, G. Otting and C. Nitsche, Chem. Commun., 2022, 58, 701 DOI: 10.1039/D1CC06497E

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