Novel cationic meso-CF3 BODIPY-based AIE fluorescent rotors for imaging viscosity in mitochondria

Wen-Jing Shi; Jinrong Yang; Yong-Feng Wei; Xiao-Tong Li; Xu-Hui Yan; Yuxuan Wang; Huaxiang Leng; Liyao Zheng; Jin-wu Yan

doi:10.1039/D1CC06532G

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Novel cationic meso-CF₃ BODIPY-based AIE fluorescent rotors for imaging viscosity in mitochondria†

Wen-Jing Shi,‡*^a Jinrong Yang,‡^b Yong-Feng Wei,^a Xiao-Tong Li,^a Xu-Hui Yan,^a Yuxuan Wang,^b Huaxiang Leng,^b Liyao Zheng

^a and Jin-wu Yan

*^b

Author affiliations

* Corresponding authors

^a School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, P. R. China
E-mail: swj114@gzhu.edu.cn

^b School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, P. R. China
E-mail: yjw@scut.edu.cn

Abstract

Two novel meso-CF₃ BODIPY-based fluorescent rotors have been rationally prepared and found to sensitively respond to viscosity in living cells with a fluorescence “turn-on” effect, attributed to the special restricted rotation of meso-CF₃ group in viscous environments. Interestingly, a monostyryl probe with one cationic group exhibits good mitochondrial localization and AIE property.

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Article information

DOI: https://doi.org/10.1039/D1CC06532G
Article type: Communication
Submitted: 22 Nov 2021
Accepted: 04 Jan 2022
First published: 04 Jan 2022

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Chem. Commun., 2022,58, 1930-1933

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Novel cationic meso-CF₃ BODIPY-based AIE fluorescent rotors for imaging viscosity in mitochondria

W. Shi, J. Yang, Y. Wei, X. Li, X. Yan, Y. Wang, H. Leng, L. Zheng and J. Yan, Chem. Commun., 2022, 58, 1930 DOI: 10.1039/D1CC06532G

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Chemical Communications