Issue 15, 2022
From the journal:

Chemical Communications

β-Galactosidase-dependent metabolic glycoengineering of tumor cells for imaging and immunotherapy†

Yanchun Li,a   Liang Gong, ORCID logo a   Haofei Hong, ORCID logo a   Han Lin,a   Dan Li,a   Jie Shi,a   Zhifang Zhou ORCID logo *a  and  Zhimeng Wu ORCID logo *a  

* Corresponding authors

a The Key Laboratory of Carbohydrate Chemistry & Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China
E-mail: zhifangzhou@jiangnan.edu.cn, zwu@jiangnan.edu.cn
Fax: +86-510-85197582
Tel: +86-510-85197582

Abstract

A β-Gal-dependent metabolic glycoengineering strategy was developed for tumor cell-selective surface glycan imaging with high efficacy. Combined with an antibody-recruiting strategy, targeted immunotherapy was achieved successfully based on this strategy.

Graphical abstract: β-Galactosidase-dependent metabolic glycoengineering of tumor cells for imaging and immunotherapy

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Article information

DOI
https://doi.org/10.1039/D1CC06575K
Article type
Communication
Submitted
23 Nov 2021
Accepted
20 Jan 2022
First published
21 Jan 2022

Chem. Commun., 2022,58, 2568-2571

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β-Galactosidase-dependent metabolic glycoengineering of tumor cells for imaging and immunotherapy

Y. Li, L. Gong, H. Hong, H. Lin, D. Li, J. Shi, Z. Zhou and Z. Wu, Chem. Commun., 2022, 58, 2568 DOI: 10.1039/D1CC06575K

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