Issue 6, 2022
From the journal:

Chemical Communications

Activatable fluorogenic probe for accurate imaging of ulcerative colitis hypoxia in vivo†

Mingrui Li,‡a   Yong Zhang,‡a   Xiaojun Ren,*a   Wenchao Niu,a   Qing Yuan,a   Kai Cao,a   Jinchao Zhang, ORCID logo b   Xueyun Gao ORCID logo a  and  Dongdong Su ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Biology, Faculty of Environment and Life Science, Beijing University of Technology, Beijing, P. R. China
E-mail: xjren@bjut.edu.cn, chmsudd@bjut.edu.cn

b College of Chemistry & Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding, 071002, P. R. China

Abstract

A simple but efficient fluorogenic probe is reported for accurate imaging of ulcerative colitis via hypoxia detection. The hypoxia produced by ulcerative colitis can lead to the upregulation of nitroreductase (NTR). NB-NO2 provides a unique response to NTR, enabling accurate imaging of Dextran sulphate sodium (DSS)-induced ulcerative colitis in vivo.

Graphical abstract: Activatable fluorogenic probe for accurate imaging of ulcerative colitis hypoxia in vivo

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Article information

DOI
https://doi.org/10.1039/D1CC06577G
Article type
Communication
Submitted
23 Nov 2021
Accepted
13 Dec 2021
First published
14 Dec 2021

Chem. Commun., 2022,58, 819-822

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Activatable fluorogenic probe for accurate imaging of ulcerative colitis hypoxia in vivo

M. Li, Y. Zhang, X. Ren, W. Niu, Q. Yuan, K. Cao, J. Zhang, X. Gao and D. Su, Chem. Commun., 2022, 58, 819 DOI: 10.1039/D1CC06577G

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