Issue 9, 2022
From the journal:

Chemical Communications

A fluorogenic RNA aptamer nanodevice for the low background imaging of mRNA in living cells†

Tingting Xu,‡a   Yao Sun,‡a   Sha Yu, ORCID logo b   Shaojun Wu,a   Yu Su,a   Ye Tian, ORCID logo *ac   Yuanzhen Zhou ORCID logo *b  and  Jun-Jie Zhu ORCID logo *ab  

* Corresponding authors

a State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
E-mail: jjzhu@nju.edu.cn, ytian@nju.edu.cn

b School of Chemistry and Chemical Engineering, Xi’an University of Architecture and Technology, Xi’an 710055, China
E-mail: zhouyuanzhen@xauat.edu.cn

c Shenzhen Research Institute of Nanjing University, Shenzhen 518000, China

Abstract

A fluorogenic RNA aptamer nanodevice integrating an entropy-driven RNA amplifier with near-infrared (NIR) light control was developed, affording high contrast and sensitivity for imaging low-abundance mRNA in living cells. The design principle offers a new approach for developing low-background imaging systems for live-cell studies and manipulation.

Graphical abstract: A fluorogenic RNA aptamer nanodevice for the low background imaging of mRNA in living cells

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Article information

DOI
https://doi.org/10.1039/D1CC06582C
Article type
Communication
Submitted
23 Nov 2021
Accepted
20 Dec 2021
First published
20 Dec 2021

Chem. Commun., 2022,58, 1354-1357

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A fluorogenic RNA aptamer nanodevice for the low background imaging of mRNA in living cells

T. Xu, Y. Sun, S. Yu, S. Wu, Y. Su, Y. Tian, Y. Zhou and J. Zhu, Chem. Commun., 2022, 58, 1354 DOI: 10.1039/D1CC06582C

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