A biodegradable amphiphilic poly(aminoester) dendrimer for safe and effective siRNA delivery

Chi Ma; Dandan Zhu; Wenyi Lin; Ying Li; Yuanzheng Huang; Huiling Zhu; Mengyun Ye; Yang Wang; Ling Peng; Xiaoxuan Liu

doi:10.1039/D1CC06655B

A biodegradable amphiphilic poly(aminoester) dendrimer for safe and effective siRNA delivery†

Chi Ma,‡^a Dandan Zhu,

‡^a Wenyi Lin,^a Ying Li,^a Yuanzheng Huang,^a Huiling Zhu,^a Mengyun Ye,^a Yang Wang,^bc Ling Peng

*^b and Xiaoxuan Liu

*^a

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* Corresponding authors

^a State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 210009, P. R. China
E-mail: xiaoxuanliu@cpu.edu.cn

^b Aix Marseille Univ, CNRS, Center Interdisciplinaire de Nanoscience de Marseille, UMR 7325, Equipe Labellisée Ligue Contre le Cancer, Marseille, France
E-mail: ling.peng@univ-amu.fr

^c Hubei Gedian Humanwell Pharmaceutical Co. Ltd., E-zhou, P. R. China

Abstract

Small interfering RNA (siRNA)-based therapeutics represent a novel and compelling drug modality, provided that safe and competent vectors are available for their delivery. Here, we report a biodegradable amphiphilic poly(aminoester) dendrimer for effective siRNA delivery. This dendrimer is readily biodegradable upon enzyme action, and harnesses the delivery features of both lipid and polymer vectors thanks to its lipid/dendrimer hybrid structure. This study opens new perspectives for developing biodegradable and biocompatible vectors for siRNA therapeutics.

Chemical Communications

A biodegradable amphiphilic poly(aminoester) dendrimer for safe and effective siRNA delivery†

Abstract

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A biodegradable amphiphilic poly(aminoester) dendrimer for safe and effective siRNA delivery

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