DNA origami nanocalipers for pH sensing at the nanoscale

Xinyue Zhang; Li Pan; Ruiyan Guo; Yueyue Zhang; Fan Li; Min Li; Jiang Li; Jiye Shi; Fengli Qu; Xiaolei Zuo; Xiuhai Mao

doi:10.1039/D1CC06701J

DNA origami nanocalipers for pH sensing at the nanoscale†

Xinyue Zhang,‡^ab Li Pan,‡^ac Ruiyan Guo,^a Yueyue Zhang,^a Fan Li,^a Min Li,^a Jiang Li,

^d Jiye Shi,^d Fengli Qu,

^b Xiaolei Zuo

^ac and Xiuhai Mao

*^a

Author affiliations

* Corresponding authors

^a Institute of Molecular Medicine, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
E-mail: maoxiuhai@sjtu.edu.cn

^b College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, Shandong, China

^c School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, China

^d Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China

Abstract

A DNA origami nanocaliper is employed as a shape-resolved nanomechanical device, with pH-responsive triplex DNA integrated into the two arms. The shape transition of the nanocaliper results in a subtle difference depending on the local pH that is visible via TEM imaging, demonstrating the potential of these nanocalipers to act as a universal platform for pH sensing at the nanoscale.

Chemical Communications

DNA origami nanocalipers for pH sensing at the nanoscale†

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DNA origami nanocalipers for pH sensing at the nanoscale

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