Issue 23, 2022

Stable high-oxidation-state complex in situ Mn(v)–Mn(iii) transition to achieve highly efficient cervical cancer therapy

Abstract

Designing metal complexes to target the vulnerable redox balance in cancer cells is a promising strategy to realize successful cancer therapy. The synthesized stable nitridomanganese(V) complex MnV(N) (salen) not only reacts with GSH to achieve in situ Mn(V)–Mn(III) transformation to down-regulate the antioxidant system, but also catalyzes H2O2 to higher oxidation capacity ROS to up-regulate the intracellular oxidative level, finally resulting in cancer cell death.

Graphical abstract: Stable high-oxidation-state complex in situ Mn(v)–Mn(iii) transition to achieve highly efficient cervical cancer therapy

Supplementary files

Article information

Article type
Communication
Submitted
04 Dec 2021
Accepted
19 Jan 2022
First published
01 Feb 2022

Chem. Commun., 2022,58, 3759-3762

Stable high-oxidation-state complex in situ Mn(V)–Mn(III) transition to achieve highly efficient cervical cancer therapy

H. Zhang, Y. Zhang, J. Cao, L. Ma and T. Chen, Chem. Commun., 2022, 58, 3759 DOI: 10.1039/D1CC06819A

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