We herein describe a novel method for miRNA detection based on target-triggered transcription of a light-up RNA aptamer (TTRApt), consequently producing a highly enhanced fluorescence signal through specific binding of a light-up RNA aptamer to the corresponding dye. Using this strategy, we successfully identified target miRNA down to 59.4 aM with excellent specificity.
S. Lee, H. Kim, Y. Park and H. G. Park, Chem. Commun., 2022, 58, 4243 DOI: 10.1039/D1CC07095A
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