Issue 29, 2022
From the journal:

Chemical Communications

Assessment of cancer cell migration using a viscosity-sensitive fluorescent probe†

Xiaohong Pan,‡ab   Cheng Wang,‡b   Congcong Zhao,‡a   Tingting Cheng,b   Aishan Zheng,a   Yuru Caoc  and  Kehua Xu ORCID logo *a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Shandong Normal University, Jinan 250014, P. R. China
E-mail: xukehua@sdnu.edu.cn

b School of Pharmacy, Binzhou Medical University, Yantai 264003, China

c The 2nd Medical College of Binzhou Medical University, Yantai 264003, China

Abstract

A novel viscosity probe (NV1) was developed for assessing cancer cell migration. NV1 can respond to changes of viscosity rapidly and exhibits high sensitivity in HepG2 cells treated with starvation, rotenone and nystatin. Importantly, NV1 was used for the first time to evaluate the relationship between intracellular viscosity changes and cancer cell migration and proved that increased intracellular viscosity inhibits cell migration while decreased intracellular viscosity promotes cell migration.

Graphical abstract: Assessment of cancer cell migration using a viscosity-sensitive fluorescent probe

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Article information

DOI
https://doi.org/10.1039/D1CC07235H
Article type
Communication
Submitted
25 Dec 2021
Accepted
10 Mar 2022
First published
11 Mar 2022

Chem. Commun., 2022,58, 4663-4666

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Assessment of cancer cell migration using a viscosity-sensitive fluorescent probe

X. Pan, C. Wang, C. Zhao, T. Cheng, A. Zheng, Y. Cao and K. Xu, Chem. Commun., 2022, 58, 4663 DOI: 10.1039/D1CC07235H

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