ZIF-8 with cationic defects toward efficient 125I2 uptake for in vitro radiotherapy of colon cancer

Xin-Xin Tian; Yi-Tong Liu; Yan Li; Xin-Yu Qiu; Wen-Hua Zhang; David J. Young; Qiu Chen

doi:10.1039/D1CC07304D

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ZIF-8 with cationic defects toward efficient ¹²⁵I₂ uptake for in vitro radiotherapy of colon cancer†

Xin-Xin Tian,‡^a Yi-Tong Liu,‡^b Yan Li,^a Xin-Yu Qiu,^b Wen-Hua Zhang,

*^a David J. Young

^c and Qiu Chen*^a

Author affiliations

* Corresponding authors

^a College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
E-mail: whzhang@suda.edu.cn

^b State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection (SRMP) of Soochow University, Suzhou 215123, China
E-mail: happyqiu@suda.edu.cn

^c College of Engineering, Information Technology & Environment, Charles Darwin University, Darwin, Northern Territory 0909, Australia

Abstract

Introducing 2,3-dimethyl-1H-imidazol-3-ium iodide (Dmim) as a monodentate ligand during the preparation of ZIF-8 yields ZIF-8 + (50) and ZIF-8 + (38) with cationic ‘missing linker’ defects. ZIF-8 + (38) adsorbs ¹²⁵I₂ and the resulting radioactive host–guest complex exhibits in vitro cytotoxicity comparable to that of Na¹²⁵I against colon cancer cell line CT26.

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Article information

DOI: https://doi.org/10.1039/D1CC07304D
Article type: Communication
Submitted: 31 Dec 2021
Accepted: 23 May 2022
First published: 23 May 2022

Download Citation

Chem. Commun., 2022,58, 6942-6945

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ZIF-8 with cationic defects toward efficient ¹²⁵I₂ uptake for in vitro radiotherapy of colon cancer

X. Tian, Y. Liu, Y. Li, X. Qiu, W. Zhang, D. J. Young and Q. Chen, Chem. Commun., 2022, 58, 6942 DOI: 10.1039/D1CC07304D

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