We developed a first-in-class proteolysis targeting chimera (PROTAC) for selective degradation of histone deacetylase 8 (HDAC8). The PROTAC induced degradation of HDAC8 without affecting the levels of other HDACs in cellular assays, and inhibited the growth of T-cell leukemia Jurkat cells more potently than a conventional HDAC8 inhibitor.
J. Chotitumnavee, Y. Yamashita, Y. Takahashi, Y. Takada, T. Iida, M. Oba, Y. Itoh and T. Suzuki, Chem. Commun., 2022, 58, 4635 DOI: 10.1039/D2CC00272H
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