Three-component addition of terminal alkynes, carboxylic acids, and tert-butyl hypochlorite

Abstract

This paper described the unprecedented three-component addition of terminal alkynes, carboxylic acids, and tert-butyl hypochlorite. This new type of addition proceeds smoothly to produce gem-dichloroalkane derivatives in satisfactory to excellent yields via successive two-time additions under mild conditions. The synthetically useful functional groups, such as Cl, Br, CN, and NO₂, remained intact in the final products.