Issue 34, 2022

Right- and left-handed PPI helices in cyclic dodecapeptoids

Abstract

Enantiomorphic right- and left-handed polyproline type I helices in four cyclic dodecapeptoids with methoxyethyl and propargyl side chains are observed for the first time by single crystal X-ray diffraction. The peculiar absence of NH⋯OC hydrogen bonds in peptoids unveils the role of intramolecular backbone-to-backbone CO⋯CO interactions and CH⋯OC hydrogen bonds in the stabilization of the macrocycle conformation. Moreover, intramolecular backbone-side chain C5 CH⋯OC hydrogen bonds emerge as a stabilizing factor.

Graphical abstract: Right- and left-handed PPI helices in cyclic dodecapeptoids

Supplementary files

Article information

Article type
Communication
Submitted
02 Feb 2022
Accepted
28 Mar 2022
First published
30 Mar 2022
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2022,58, 5253-5256

Right- and left-handed PPI helices in cyclic dodecapeptoids

G. Pierri, R. Schettini, F. F. Summa, F. De Riccardis, G. Monaco, I. Izzo and C. Tedesco, Chem. Commun., 2022, 58, 5253 DOI: 10.1039/D2CC00682K

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