Issue 39, 2022
From the journal:

Chemical Communications

Proline selective labeling via on-site construction of naphthoxazole (NapOx)†

Subhra Kanti Roy,a   Anisha Purkait,a   Rajib Shome,b   Saurav Das, ORCID logo a   Debapratim Das, ORCID logo a   Siddhartha Sankar Ghosh ORCID logo b  and  Chandan K. Jana ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology Guwahati, India
E-mail: ckjana@iitg.ac.in

b Department of Biosciences and Engineering, Indian Institute of Technology Guwahati, India

Abstract

Chemoselective construction of naphthoxazoles (NapOx) via a three-component annulation reaction enables proline selective labeling of peptides in solution or in solid-phase synthesis. The fluorogenic peptides possess low cytotoxicity, efficient cell membrane permeability and excellent bioimaging potential for biomedical applications.

Graphical abstract: Proline selective labeling via on-site construction of naphthoxazole (NapOx)

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Article information

DOI
https://doi.org/10.1039/D2CC01268E
Article type
Communication
Submitted
02 Mar 2022
Accepted
19 Apr 2022
First published
20 Apr 2022

Chem. Commun., 2022,58, 5909-5912

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Proline selective labeling via on-site construction of naphthoxazole (NapOx)

S. K. Roy, A. Purkait, R. Shome, S. Das, D. Das, S. S. Ghosh and C. K. Jana, Chem. Commun., 2022, 58, 5909 DOI: 10.1039/D2CC01268E

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