Issue 44, 2022
From the journal:

Chemical Communications

Water-soluble bright NIR AIEgens with hybrid ROS for wash-free mitochondrial “off–on” imaging and photodynamic therapy†

Fang-Zhou Xu,a   Cheng-Yun Wang, ORCID logo *a   Qi Wang, ORCID logo a   Jian-Wei Zou,b   Yi-Jie Qiao,a   Zhi-Qian Guo, ORCID logo a   Weijun Zhao ORCID logo *a  and  Wei-Hong Zhu ORCID logo *a  

* Corresponding authors

a Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, P. R. China
E-mail: cywang@ecust.edu.cn, zhwj@ecust.edu.cn, whzhu@ecust.edu.cn

b NingboTech University, Ningbo, Zhejiang, P. R. China

Abstract

Several aggregation-induced emission luminogens (AIEgens) with excellent water-solubility and near-infrared emission were designed and synthesized for wash-free “off–on” mitochondrial imaging and photodynamic therapy of HeLa cells. The AIEgen TEPP exhibits both bright near-infrared emission (φF = 17.8%) and high hybrid ROS productivity (including OH˙ and 1O2).

Graphical abstract: Water-soluble bright NIR AIEgens with hybrid ROS for wash-free mitochondrial “off–on” imaging and photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/D2CC01559E
Article type
Communication
Submitted
18 Mar 2022
Accepted
28 Apr 2022
First published
29 Apr 2022

Chem. Commun., 2022,58, 6393-6396

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Water-soluble bright NIR AIEgens with hybrid ROS for wash-free mitochondrial “off–on” imaging and photodynamic therapy

F. Xu, C. Wang, Q. Wang, J. Zou, Y. Qiao, Z. Guo, W. Zhao and W. Zhu, Chem. Commun., 2022, 58, 6393 DOI: 10.1039/D2CC01559E

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