Issue 44, 2022
From the journal:

Chemical Communications

β-Galactosidase-activated theranostic for hepatic carcinoma therapy and imaging†

Mrinmoy Maiti,‡a   Kai Kikuchi, ORCID logo ‡bc   K. K. Athul,d   Amandeep Kaur ORCID logo *bc  and  Sankarprasad Bhuniya ORCID logo *d  

* Corresponding authors

a Department of Science, Amrita School of Engineering, Amrita Viswa Vidyapeetham, Coimbatore, India

b School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, NSW 2006, Australia
E-mail: a.kaur@sydney.edu.au

c The University of Sydney Nano Institute, The University of Sydney, NSW 2006, Australia

d Centre for Interdisciplinary Sciences, JIS Institute of Advanced Studies and Research, JIS University, Arch Waterfront, GP Block, Sector V, Kolkata, India
E-mail: spbhuniya@jisiasr.org

Abstract

A β-galactosidase activatable fluorescent turn-on theranostic Gal-CGem exhibits gemcitabine release specifically in β-galactosidase overexpressing hepatic carcinoma cells. The cytotoxicity of Gal-CGem in cancer cells is achieved through the apoptotic cell death pathway. Overall, Gal-CGem is a new frontline prodrug in cancer therapy that has provided antineoplastic information through fluorescence imaging.

Graphical abstract: β-Galactosidase-activated theranostic for hepatic carcinoma therapy and imaging

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Article information

DOI
https://doi.org/10.1039/D2CC01825J
Article type
Communication
Submitted
30 Mar 2022
Accepted
03 May 2022
First published
03 May 2022

Chem. Commun., 2022,58, 6413-6416

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β-Galactosidase-activated theranostic for hepatic carcinoma therapy and imaging

M. Maiti, K. Kikuchi, K. K. Athul, A. Kaur and S. Bhuniya, Chem. Commun., 2022, 58, 6413 DOI: 10.1039/D2CC01825J

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