Issue 46, 2022

Palladium-catalyzed cross-coupling of unreactive C(sp3)–H bonds with azole C(sp2)–H bonds by using bromide as a traceless directing group

Abstract

A palladium-catalyzed intermolecular cross-coupling of unreactive C(sp3)–H bonds and azole C(sp2)–H bonds with bromide as a traceless directing group is described. The judicious selection of the bulky and electron-rich phosphine ligand is the key for the success of this cascade process. The protocol features a broad substrate scope, excellent regioselectivity, and good functional group tolerance.

Graphical abstract: Palladium-catalyzed cross-coupling of unreactive C(sp3)–H bonds with azole C(sp2)–H bonds by using bromide as a traceless directing group

Supplementary files

Article information

Article type
Communication
Submitted
05 Apr 2022
Accepted
12 May 2022
First published
12 May 2022

Chem. Commun., 2022,58, 6661-6664

Palladium-catalyzed cross-coupling of unreactive C(sp3)–H bonds with azole C(sp2)–H bonds by using bromide as a traceless directing group

Y. Chen, J. Fu, X. Ji, S. Zhang and C. Feng, Chem. Commun., 2022, 58, 6661 DOI: 10.1039/D2CC01944B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements