Issue 61, 2022
From the journal:

Chemical Communications

Cancer cell membrane targeting and red light-triggered carbon monoxide (CO) release for enhanced chemotherapy†

Wei-Nan Zhao,a   Min Wang,b   Chen Zhang,c   Shiguo Sun ORCID logo a  and  Yongqian Xu ORCID logo *a  

* Corresponding authors

a Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A & F University, Yangling, Shaanxi, P. R. China
E-mail: xuyq@nwsuaf.edu.cn

b College of Chemistry, Fuzhou University, Fuzhou, P. R. China

c College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, P. R. China

Abstract

Chemotherapy assisted by carbon monoxide (CO) gas therapy is an emerging powerful cancer therapeutic modality. However, the effective delivery and controlled release of CO in tumor cells remain a challenge. Herein, a cell membrane bionic nano delivery system (RBC-H@DOX/3-HF@MSN, termed as RHM) was designed to selectively accumulate in tumors and generate CO in situ upon red light irradiation for the combination of chemotherapy and gas therapy. CO significantly improves the therapeutic effect of DOX from 29.0% to 82.4%.

Graphical abstract: Cancer cell membrane targeting and red light-triggered carbon monoxide (CO) release for enhanced chemotherapy

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Article information

DOI
https://doi.org/10.1039/D2CC01948E
Article type
Communication
Submitted
05 Apr 2022
Accepted
29 Jun 2022
First published
30 Jun 2022

Chem. Commun., 2022,58, 8512-8515

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Cancer cell membrane targeting and red light-triggered carbon monoxide (CO) release for enhanced chemotherapy

W. Zhao, M. Wang, C. Zhang, S. Sun and Y. Xu, Chem. Commun., 2022, 58, 8512 DOI: 10.1039/D2CC01948E

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