Issue 86, 2022
From the journal:

Chemical Communications

A pH-responsive cascade nanoplatform with circulating oxygen supply for collaborative breast cancer treatment†

Xiaonan Gao, ORCID logo ‡a   Zhikai Jia,‡a   Yaoying Cheng,a   Mingyi Ouyang,a   Lin Feng,a   Yuzhuo Wang,a   Bo Tang ORCID logo *a  and  Kehua Xu ORCID logo *a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, P. R. China
E-mail: tangb@sdnu.edu.cn, xukehua@sdnu.edu.cn

Abstract

A pH-responsive cascade nanoplatform based on ZIF-8 disintegrates in the weakly acidic tumor microenvironment to release MnO2, CaO2 and Ce6. The drugs can cyclically generate O2 for sonodynamic therapy, consume glutathione to tune the redox hemostasis, and produce cytotoxic ˙OH to kill tumor cells via chemical dynamics therapy.

Graphical abstract: A pH-responsive cascade nanoplatform with circulating oxygen supply for collaborative breast cancer treatment

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Article information

DOI
https://doi.org/10.1039/D2CC02044K
Article type
Communication
Submitted
11 Apr 2022
Accepted
26 Sep 2022
First published
08 Oct 2022

Chem. Commun., 2022,58, 12090-12093

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A pH-responsive cascade nanoplatform with circulating oxygen supply for collaborative breast cancer treatment

X. Gao, Z. Jia, Y. Cheng, M. Ouyang, L. Feng, Y. Wang, B. Tang and K. Xu, Chem. Commun., 2022, 58, 12090 DOI: 10.1039/D2CC02044K

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