The capture and detection of cells expressing a breast-cancer related membrane protein, namely a BT474 cell line expressing HER2, is demonstrated using ion-sensitive field effect transistors (ISFETs). BT474 cells were exposed to anti-HER2 antibodies and urease-conjugated secondary antibodies to induce chemical signal amplification by adding urea.
M. Tabata, C. Khamhanglit, S. Kotaki and Y. Miyahara, Chem. Commun., 2022, 58, 7368 DOI: 10.1039/D2CC02159E
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