Issue 58, 2022
From the journal:

Chemical Communications

A universal DNA aptamer as an efficient inhibitor against spike-protein/hACE2 interactions†

Achut Prasad Silwal,a   Raunak Jahan,a   Siddhartha Kalpa Samadhi Thennakoon,a   Satya Prakash Arya,a   Rick Mason Postema,a   Elizabeth Claire Vander Arka  and  Xiaohong Tan ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio, USA
E-mail: tanx@bgsu.edu

Abstract

A universal aptamer against spike-proteins of diverse SARS-CoV-2 variants was discovered via DNA SELEX towards the wild-type (WT) spike-protein. This aptamer, A1C1, binds to the WT spike-protein or other variants of concern such as Delta and Omicron with low nanomolar affinities. A1C1 inhibited the interaction between hACE2 and various spike-proteins by 85–89%. This universal A1C1 aptamer can be used to design diagnostic and therapeutic molecular tools to target SARS-CoV-2 and its variants.

Graphical abstract: A universal DNA aptamer as an efficient inhibitor against spike-protein/hACE2 interactions

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Article information

DOI
https://doi.org/10.1039/D2CC02647C
Article type
Communication
Submitted
10 May 2022
Accepted
17 Jun 2022
First published
24 Jun 2022

Chem. Commun., 2022,58, 8049-8052

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A universal DNA aptamer as an efficient inhibitor against spike-protein/hACE2 interactions

A. P. Silwal, R. Jahan, S. K. S. Thennakoon, S. P. Arya, R. M. Postema, E. C. Vander Ark and X. Tan, Chem. Commun., 2022, 58, 8049 DOI: 10.1039/D2CC02647C

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