Issue 83, 2022

Nuclear Overhauser spectroscopy in hyperpolarized water – chemical vs. magnetic exchange

Abstract

Dissolution dynamic nuclear polarization (dDNP) is a versatile hyperpolarization technique to boost signal intensities in nuclear magnetic resonance (NMR) spectroscopy. The possibility to dissolve biomolecules in a hyperpolarized aqueous buffer under mild conditions has recently widened the scope of NMR by dDNP. The water-to-target hyperpolarization transfer mechanisms remain yet unclear, not least due to an often-encountered dilemma of dDNP experiments: The strongly enhanced signal intensities are accompanied by limited structural information as data acquisition is restricted to short time series of only one-dimensional spectra or a single correlation spectrum. Tackling this challenge, we combine dDNP with molecular dynamics (MD) simulations and predictions of cross-relaxation rates to unravel the spin dynamics of magnetization flow in hyperpolarized solutions.

Graphical abstract: Nuclear Overhauser spectroscopy in hyperpolarized water – chemical vs. magnetic exchange

Supplementary files

Article information

Article type
Communication
Submitted
05 Jul 2022
Accepted
21 Sep 2022
First published
21 Sep 2022
This article is Open Access
Creative Commons BY license

Chem. Commun., 2022,58, 11661-11664

Nuclear Overhauser spectroscopy in hyperpolarized water – chemical vs. magnetic exchange

L. M. Epasto, P. Honegger, K. Che, F. Kozak, F. Jörg, C. Schröder and D. Kurzbach, Chem. Commun., 2022, 58, 11661 DOI: 10.1039/D2CC03735A

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