Issue 92, 2022

Catalytic methoxylation of aryl halides using 13C- and 14C-labeled CO2

Abstract

The functionalization of carbon dioxide (CO2) into high-value building blocks is a relevant topic in carbon isotope labeling, where CO2 is the primary carbon source. A catalytic methoxylation of aryl halides directly from [13C] and [14C]CO2 is reported. Relying on the intermediacy of the methoxyborane BBN-OCH3, as a new secondary nucleophilic labeled source, this strategy allowed labeling of a series of substrates, including challenging pharmaceuticals containing tertiary alkyl amine substituents.

Graphical abstract: Catalytic methoxylation of aryl halides using 13C- and 14C-labeled CO2

Supplementary files

Article information

Article type
Communication
Submitted
05 Jul 2022
Accepted
30 Sep 2022
First published
06 Oct 2022
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2022,58, 12831-12834

Catalytic methoxylation of aryl halides using 13C- and 14C-labeled CO2

A. Ohleier, A. Sallustrau, B. Mouhsine, F. Caillé, D. Audisio and T. Cantat, Chem. Commun., 2022, 58, 12831 DOI: 10.1039/D2CC03746G

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