Issue 77, 2022
From the journal:

Chemical Communications

A photo-activated aptamer–drug conjugate for targeted drug delivery†

Jing Liu,ab   Xiangjun Liu, ORCID logo *ab   Mengwen Yi,a   Yue Sun,a   Tao Bing, ORCID logo ab   Nan Zhanga  and  Dihua Shangguan ORCID logo *abc  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
E-mail: xjliu@iccas.ac.cn, sgdh@iccas.ac.cn

b University of Chinese Academy of Sciences, Beijing, China

c School of Molecular Medicine, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China

Abstract

A photo-activated aptamer–drug conjugate, HG1-9–DNP, was developed based on an aptamer HG1-9 and a photolabile naphthalimide derivative DNP. HG1-9–DNP could be internalized into cells mediated by TfR, then photocleaved, and released a promising cytotoxic agent, DNNH, which arrested the cell cycle at the G2/M phase, resulting in high photo-induced cytotoxicity.

Graphical abstract: A photo-activated aptamer–drug conjugate for targeted drug delivery

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Article information

DOI
https://doi.org/10.1039/D2CC04045J
Article type
Communication
Submitted
20 Jul 2022
Accepted
30 Aug 2022
First published
30 Aug 2022

Chem. Commun., 2022,58, 10797-10800

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A photo-activated aptamer–drug conjugate for targeted drug delivery

J. Liu, X. Liu, M. Yi, Y. Sun, T. Bing, N. Zhang and D. Shangguan, Chem. Commun., 2022, 58, 10797 DOI: 10.1039/D2CC04045J

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